Phenotypic Characterization Murine Sarcoma TG-180 Immunophenotypical Characterization Murine Sarcoma TG-180
نویسندگان
چکیده
منابع مشابه
Conversion of 6-thioguanine to the nucleoside level by purine nucleoside phosphorylase of sarcoma 180 and sarcoma 180/TG ascites cells.
Tumor sublines sensitive (Sarcoma 180) and resistant (Sar coma 180/TG) to the cytotoxic action of 6-thioguanine (6TG) actively metabolize the 6-thiopurine to 6-thioguanosine (6TGuo). The conversion of 6TG to 6TGuo by intact cells was enhanced by D-ribose 1-phosphate but not by D-ribose 5phosphate. This corresponded to the finding that D-ribose 1phosphate supported the synthesis of 6TGuo from 6T...
متن کاملStudies with mouse sarcoma 180.
Negative results are reported for five compounds tested against mouse Sarcoma 180. Twelve mice, 18 gm. Rockland and Carworth Farms mice, were used for each test. The tumors were implanted subcutaneously by trocar in the right axilla. When the implants were seven days old the compounds were in jected intraperitoneallytwice a day for seven days. The compounds were tested at the maximum non-lethal...
متن کاملDifferential expression of intermediate-filament proteins in murine sarcoma 180 ascites or solid tumor.
The intermediate-filament proteins in Sarcoma 180 ascites cells and solid tumors generated by s.c. injection of ascites cells in NMRI or nude mice were analyzed by one- and two-dimensional gel electrophoresis and identified by immunological methods. The ascites form of Sarcoma 180 coexpresses keratin and vimentin, whereas the solid tumor ceases to synthesize keratins but continues to express vi...
متن کاملInosinic acid dehydrogenase of sarcoma 180 cells.
Inosinic acid dehydrogenase was partially purified from sarcoma 180 cells. The concentrations of each reactant, inosine 5’-phosphate, nicotinamide adenine dinucleotide, and K+, altered both the apparent K, and Vmaxvalues for each of the other reactants. Enzymatic activity was inhibited by both products of the reaction, xanthosine S-phosphate and reduced nicotinamide adenine dinucleotide; the in...
متن کاملGrowth of Sarcoma 180 in adrenalectomized mice.
Sarcoma 180 grew for only 10-14 days when implanted in bilaterally adrenalectomized male Swiss mice. The tumors completely regressed within 30 days. Untreated adrenalectomized mice never had tumors larger than 15 mm. in diameter. Adrenalectomy of mice after the tumor was established also resulted in regression of Sarcoma 180. Daily injections of Cortisol acetate or corticosterone at dosages fro...
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ژورنال
عنوان ژورنال: Open Journal of Pathology
سال: 2015
ISSN: 2164-6775,2164-6783
DOI: 10.4236/ojpathology.2015.52009